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Understanding the ability of particles to maneuver through disordered environments is a central problem in innumerable settings, from active matter and biology to electronics. Macroscopic particles ultimately exhibit diffusive motion when their energy exceeds the characteristic potential barrier of the random landscape. In stark contrast, wave-particle duality causes electrons in disordered media to come to rest even when the potential is weak—a remarkable phenomenon known as Anderson localization. Here, we present a hydrodynamic active system with wave-particle features, a millimetric droplet self-guided by its own wave field over a submerged random topography, whose dynamics exhibits localized statistics analogous to those of electronic systems. Consideration of an ensemble of particle trajectories reveals a suppression of diffusion when the guiding wave field extends over the disordered topography. We rationalize mechanistically the emergent statistics by virtue of the wave-mediated resonant coupling between the droplet and topography, which produces an attractive wave potential about the localization region. This hydrodynamic analog, which demonstrates how a classical particle may localize like a wave, suggests new directions for future research in various areas, including active matter, wave localization, many-body localization, and topological matter. Published by the American Physical Society2024